http://www.chrisjakobson.com/about-us daily 1.0 2025-04-16 http://www.chrisjakobson.com/publications daily 0.75 2026-03-06 https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/df10024f-4eb3-45d3-b87d-7227f74157e9/pQtn.jpg publications 22. Jakobson, C.†, Hartl, J.†, Trebulle, P., Mulleder, M., Jarosz, D.#, and Ralser, M.#. (2025) “A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness.” Science. DOI: 10.1126/science.adu3198. Paper Zenodo Github Featured in Stanford Medicine Magazine https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/1f7e19b9-11e1-4516-98f6-07af6e84e817/Mutagenesis.png publications 21. Van Elgort, A., Jakobson, C., Byers, J., Futia, R., Chen, Y., Lozanoski, T., Harvey, Z., Xie, J.L., Garcia, D., and Jarosz, D. “Adaptive Variation in Mutagenesis Driven by Protein Self-Assembly.” In revision; pre-print available on SSRN. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5177180 Pre-print https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/92412903-8415-4c99-ba3c-6361a344b6ad/pop_gen.jpg publications 20. Jakobson, C., Van Elgort, A., Aguilar-Rodríguez, J., and Jarosz, D. “Protein structure shapes natural genetic variation and de novo adaptation.” bioRxiv: https://www.biorxiv.org/content/10.64898/2025.12.19.695599v1. Pre-print Github https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/ea89b991-b0e4-4bb7-a166-272099e1de27/Hsp90.jpg publications 19. Jakobson, C.†, Aguilar-Rodríguez, J.†, and Jarosz, D. “Hsp90 shapes adaptation by controlling the fitness consequences of regulatory variation.” bioRxiv: https://www.biorxiv.org/content/10.1101/2023.10.30.564848v2. Pre-print Github https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/4ccab5bb-f9b0-4fa5-882f-b3ea4d33de00/Hsp90_review.jpg publications 18. Aguilar-Rodríguez, J.†, Jakobson, C.†, and Jarosz, D. (2024) “The Hsp90 molecular chaperone as a global modifier of the genotype-phenotype-fitness map: An evolutionary perspective.” Journal of Molecular Biology. DOI: 10.1016/j.jmb.2024.168846. [Review] Paper https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/aff4fafc-a60f-4448-a32d-0ebbf2b61788/Pus4.jpg publications 17. Garcia, D.†, Campbell, E.†, Jakobson, C., Tsuchiya, M., Shaw, E., DiNardo, A., Kaeberlein, M., and Jarosz, D. (2021) “A prion accelerates proliferation at the expense of lifespan.” eLife. DOI: 10.7554/eLife.60917. Paper https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/8ae49cd4-8ca2-418b-84e5-679e445e1575/annual_review.gif publications 16. Jakobson, C. and Jarosz, D. (2020) “What Has a Century of Quantitative Genetics Taught Us About Nature’s Genetic Toolkit?” Annual Review of Genetics. DOI: 10.1146/annurev-genet-021920-102037. [Review] Paper https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/38082344-79f5-4305-9400-6b19f1f7c694/Smaug.jpg publications 15. Itakura, A.†, Chakravarty, A.†, Jakobson, C., and Jarosz, D. (2019) “Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae.” Molecular Cell. DOI: 10.1016/j.molcel.2019.10.027. Paper https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/14989b35-ba93-4983-a7c4-958040f3acfb/xlc.jpg publications 14. Jakobson, C. and Jarosz, D. (2019) “Molecular origins of complex heritability in natural genotype-to-phenotype relationships.” Cell Systems. DOI: 10.1016/j.cels.2019.04.002. Paper Cell Systems Featured Article May 2019 https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/88bb318e-51c0-409e-b3a1-17d09155e143/nutrient_mapping.jpg publications 13. Jakobson, C., She, R., and Jarosz, D. (2019) “Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae.” Nature Communications. DOI: 10.1038/s41467-019-09166-1. Paper http://www.chrisjakobson.com/not-science daily 0.75 2025-09-23 http://www.chrisjakobson.com/science daily 0.75 2025-10-11 https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/7b57de0d-17e8-448b-8d71-c84323852bfe/research_summary.jpg science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/62e2e597-ff6c-4f0b-b038-d11cf0d8b047/bubble_plot.jpg science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/bb0756b1-19a8-44b4-9b13-ac57341ffd96/chaperones.jpg science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5732142b60b5e942e750cbc5/50e487cb-8805-4eba-a0b1-acd2b6c3d12c/directed_evolution.jpg science - Make it stand out Whatever it is, the way you tell your story online can make all the difference.